Paternal age and reproduction
نویسندگان
چکیده
منابع مشابه
Paternal age and reproduction.
BACKGROUND Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring,...
متن کاملPaternal age predicts offspring chances of marriage and reproduction.
OBJECTIVES Mutation-selection balance theory proposes that a balance of forces between constantly arising mildly harmful mutations and selection causes variation in genetic configuration and phenotypic condition. As mutations are predominantly deleterious, the entry of variation due to mutations is kept at low frequencies by selection. It has recently been demonstrated that nearly all de novo m...
متن کاملAdvancing paternal age and autism.
CONTEXT Maternal and paternal ages are associated with neurodevelopmental disorders. OBJECTIVE To examine the relationship between advancing paternal age at birth of offspring and their risk of autism spectrum disorder (ASD). DESIGN Historical population-based cohort study. SETTING Identification of ASD cases from the Israeli draft board medical registry. PARTICIPANTS We conducted a stu...
متن کاملPaternal age and congenital malformations.
BACKGROUND Spontaneous mutations in germ cells increase with male age, but an association between paternal age and congenital malformations is not well established. We conducted a population-based cohort study to estimate this association. METHODS A study population of couples and their firstborn children were identified in the Danish Fertility Database between 1980 and 1996 (n = 71937). Diag...
متن کاملPaternal Age, Paternal Presence and Children’s Health: An Observational Study
In an observational study of 31,257 children we investigated the effects of paternal age at the time of the child's birth, paternal absence and non-biological fathers on children's health. Results are per 5 year change in paternal age. Older fathers were associated with lower rates of unintentional injuries, odds ratio (OR)=0.966, P=0.0027. There was a quadratic association between paternal age...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 2009
ISSN: 1460-2369,1355-4786
DOI: 10.1093/humupd/dmp027